Antidepressant Medications

Dosage, Type, Side Effects and Action

generic / TRADE

or

TRADE/generic

Daily

Dose mg

 Type Sedation Overdose Toxicity Anticho-linergic

Effects

 Cardio-

vascular Effects

 Nausea & Vomiting Seizures NE Action 5-HT Action
ADAPIN* doxepin 75-300 TCA ++++ ++++ +++ +++ + ++ +++ ++
ANAFRANIL clomipramine 75-300 TCA ++++ ++++ ++++ ++++ + +++ 0 +++++
amitriptyline ELAVIL 75-300 TCA ++++ ++++ ++++ ++++ + ++ + ++++
amoxapine ASCENDIN 150-400 2nd Gen +++ ++++ ++++ ++ + +++ +++++ +
ASCENDIN amoxapine 150-400 2nd Gen +++ ++++ ++++ ++ + +++ ++++ +
AVENTYL nortriptyline 50-150 TCA +++ ++++ +++ ++ + ++ +++ ++
bupropionD WELLBUTRINZYBAN 150-400 2nd Gen 0 0 + 0 + ++? 0 0
CELEXA citalopram 20-60 SSRI   0 0 0        
Citalopram CELEXA 20-60 SSRI                
clomipramine ANAFRANIL 75-300 TCA ++++ ++++ ++++ ++++ + +++ 0 +++++
desipramine NORPRAMIN 75-300 TCA ++ ++++ ++ +++ + ++ +++++ 0
DESYREL trazodone 150-400 2nd Gen +++ + 0 + + 0 0 +++++
doxepin* SINEQUAN 75-300 TCA ++++ ++++ +++ +++ + ++ +++ ++
EFFEXORD venlafaxine 75-225 SSRI + 0 +0 ++ ++ + ++ +++
ELAVIL amitriptyline 75-300 TCA ++++ ++++ ++++ ++++ + ++ + ++++
fluoxetine PROZAC 20-80 SSRI + 0 0 0 +++ + 0 +++++
fluvoxamine LUVOX 100-300 SSRI ++ 0 +/- 0 ++++ 0 0 +++++
imipramine TOFRANIL 75-300 TCA ++ ++++ +++ ++++ + ++ ++ +++
isocarboxazid MARPLAN 10-50 MAOI 0 ++ 0 ++ +/- +/- 0 0
LUDIOMIL maprotiline 75-225 2nd Gen +++ ++++ +++ +++ + +++ +++++ 0
LUVOX fluvoxamine 100-300 SSRI ++ 0 +/- 0 ++++ 0 0 +++++
maprotiline LUDIOMIL 75-225 2nd Gen +++ ++++ +++ +++ + +++ +++++ 0
MARPLAN isocarboxazid 10-50 MAOI 0 ++ 0 ++ +/- +/- 0 0
mirtazapine REMERON 15-45                  
NARDIL phenelzine 15-90 MAOI 0 ++ 0 ++ +/- +/- 0 0
nefrazodone SERZONE 100-500 New ++ 0 +/0 + ++ 0 0 +++++
NORPRAMIN desipramine 75-300 TCA ++ ++++ ++ +++ + ++ +++++ 0
nortiptyline PAMELOR 50-150 TCA +++ ++++ +++ ++ + ++ +++ ++
PAMELOR nortriptyline 50-150 TCA +++ ++++ +++ ++ + ++ +++ ++
PARNATE tranylcypromine 10-60 MAOI 0 ++ 0 ++ +/- +/- 0 0
paroxetine PAXIL 20-60 SSRI ++ 0 +/- 0 +++ 0 0 +++++
PAXIL paroxetine 20-60 SSRI ++ 0 +/- 0 +++ 0 0/+? +++++
Phenelzine NARDIL 15-90 MAOI 0 ++ 0 ++ +/- +/- 0 0
Protriptyline VIVACTIL 15-60 TCA + ++++ +++ +++ + + ++++ +
PROZAC fluoxetine 20-80 SSRI + 0 0 0 +++ + 0 +++++
PROZAC Weekly fluoxetine   SSRI + 0 0 0 +++ + 0 +++++
REMERON mirtazapine 15-45 New                
SARAFEM Fluoxetine   SSRI                
Sertraline ZOLOFT 50-200 SSRI + 0 0 0 +++ 0 0 +++++
SERZONE nefazodone 100-500 New ++ 0 +/0 + ++ 0 0 +++++
SINEQUAN* doxepin 75-300 TCA ++++ ++++ +++ +++ + ++ + ++++
SURMONTIL* trimipramine 75-200 TCA ++++ ++++ ++++ ++++ + ++ ++ ++
TOFRANIL imipramine 75-300 TCA ++ ++++ +++ ++++ + ++ ++ +++
tranylcypromine PARNATE 10-60 MAOI 0 ++ 0 ++ +/- +/- 0 0
trazodone DESYREL 150-400 2nd Gen ++++ ++++ +++ +++ + ++ 0 +++++
trimipramine SURMONTIL 75-200 TCA ++++ ++++ ++++ ++++ + ++ + +++++
venlafaxine D EFFEXOR 75-225 SSRI + 0 +0 ++ ++ + ++ +++
VIVACTIL * protriptyline 15-60 TCA + ++++ +++ +++ + + ++++ +
WELLBUTRIN D bupropion 150-400 2nd Gen 0 0 + 0 + ++? 0 0
ZOLOFT sertraline 50-200 SSRI + 0 0 0 +++ 0 0 +++++
ZYBAN bupropion 150-300 2nd Gen 0 0 + 0 + ++? 0 0

TCA: Tricyclics MAOI: MAO Inhibitors. Extreme high blood pressure with certain foods, over the counter and prescription drugs.

2nd Gen: 2nd generation SSRI: Selective Serotonin Reuptake Inhibitors. Side effects tend to be activating- insomnia, restlessness, sexual dysfunction; NE: Norepinephrine; 5HT: Serotonin

Anticholinergic Effects: Dry mouth, urinary hesitancy, blurred near vision, increased heart rate, interference with short term memory, undesired sedation, constipation; Cardiovascular effects: Low blood pressure, Rapid heart beat, arrythmia change (TCA’s require close monitoring with cardiovascular disease.) D Probably Dopamine Action; * Likely action of antidepressant

+ to +++++: approximate low to high action or effect. Dosage ranges from various authorities, not all agreeing., Presented as a general guideline, not to supercede the packaging guidelines.

Copyright 2002, John Swank